Our research focuses on the pathogenesis and treatment of human adrenal disorders. These research initiatives are closely connected to our clinical efforts in the BWH Center for Adrenal Disorders. We conduct human physiology studies to gain insights into adrenal hormone biology, and in parallel perform longitudinal cohort and intervention studies to understand the health implications of these physiologic observations.
What Are Adrenal Diseases?
The adrenal glands are located on top of each kidney. They are specialized organs that produce vital steroid chemicals (such as cortisol, aldosterone, and sex hormones) as well as catecholamines (such as adrenaline). Adrenal disorders can involve states of hormone excess or deficiency, which can result in substantial physical and/or emotional morbidity. Adrenal disorders may manifest as benign or malignant tumors which may or may not produce excess adrenal hormones. Recent discoveries have accelerated our understanding of the genetic origins of these conditions, as well as novel ways to treat and monitor these conditions.
2018 Update: Our series of cohort studies evaluating the efficacy of currently recommended treatments for primary aldosteronism were published in The Lancet Diabetes & Endocrinology, JAMA Cardiology, and Hypertension.
2018 Update: Our international collaborative published new findings implicating EPAS1 mutations in paragangliomas of patients with cyanotic congenital heart disease in the New England Journal of Medicine
2017 Update: A review article on Aging and Aldosterone Production published in collaboration with the Rainey Lab at the University of Michigan.
2017 Update: Dr. Vaidya discusses the lab's new research on Subclinical Primary Aldosteronism published in Annals of Internal Medicine.
2017 Update: The Vaidya Lab publishes new studies on primary aldosteronism pathophysiology and treatment in Annals of Internal Medicine and The Lancet Diabetes & Endocrinology.
2016 Update: Dr. Vaidya discusses the lab's new research on "non-functional" adrenal tumors published in Annals of Internal Medicine.