Our research focuses on human adrenal disorders and tumors. We conduct human physiology studies, deep phenotyping protocols, and prospective studies to gain insightsinto adrenal hormone biology. Our major efforts have focused on characterizing the syndrome of primary aldosteronism, the distribution of clinically relevant adrenal hormone excess that imparts adverse health effects, the pathogenesis and treatment of adrenal tumors, and improving quality of life for patients with adrenal insufficiency.
Our lab is part of the Center for Adrenal Disorders at Brigham and Women's Hospital, Harvard Medical School.
Recent Lab Updates
2021 Update: Nick Yozamp demonstrates the clinical implications of the variability of aldosterone production in primary aldosteronism in Hypertension and American Journal of Hypertension, and highlights how ACTH-stimulation during adrenal venous sampling can influence interpretations (in Hypertension).
.2021 Update: Our multi-site studies, in collaboration with the Mayo Clinic, focused on better understanding determinants of quality of life, and the impact of the COVID-19 pandemic, in patients with adrenal insufficiency, were published in JCEM.
2020 Update: Jen Brown's study characterized the unrecognized prevalence of the primary aldosteronism syndrome. This multi-site study in Annals of Internal Medicine redefines primary aldosteronism as a common syndrome that can manifest across a broad continuum of severity. Editorial by Prof. John Funder.
2020 Update: Omar Bayomy's study in JCEM disentangles the relationships between sodium, volume, RAAS activity, and calcium physiology. Findings provide potential evolutionary and practical evidence affirming the link between dietary sodium intake and kidney stones.
2020 Update: Angela Chen's study in Clinical Endocrinology highlights how variability in dietary sodium intake can influence the interpretation of cortisol measurements.
2019 Update: Our case-based overview on the management of Incidentally Discovered Adrenal Masses for AACE.
2018 Update: Our comprehensive and contemporary review on the Expanding Spectrum of Primary Aldosteronism was published in Endocrine Reviews.
2018 Update: Greg Hundemer's cohort studies evaluating the efficacy of currently recommended treatments for primary aldosteronism were published in The Lancet Diabetes & Endocrinology, JAMA Cardiology, and Hypertension.
2018 Update: Our international collaborative published new findings implicating EPAS1 mutations in paragangliomas of patients with cyanotic congenital heart disease in the New England Journal of Medicine
2017 Update: A review article on Aging and Aldosterone Production published in collaboration with the Rainey Lab at the University of Michigan.
2017 Update: The lab's new research on Subclinical Primary Aldosteronism published in Annals of Internal Medicine.
2017 Update: The Vaidya Lab publishes new studies on primary aldosteronism pathophysiology and treatment in Annals of Internal Medicine and The Lancet Diabetes & Endocrinology.
2016 Update: Dr. Vaidya discusses the lab's new research on "non-functional" adrenal tumors published in Annals of Internal Medicine.